Children inherit four times as many new mutations from their fathers than their mothers, according to research that suggests faults in the men’s DNA are a driver for rare childhood diseases.
Researchers studied 14,000 Icelanders and found that men passed on one new mutation for every eight months of age, compared with women who passed on a new mutation for every three years of age.
The figures mean that a child born to 30-year-old parents would, on average, inherit 11 new mutations from the mother, but 45 from the father.
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Issue 11, Volume 1